Epigran Protein

Nutritional Aid for Wound Healing

Prevalence of malnutrition in hospital is predicted at 86%, nursing home at 67%.¹
Individuals with malnutrition in combination with multiple comorbidities are at increased risk of developing a Pressure Injury.³
Poor nutrition is one of the reason that impede wound healing⁴
Well-nourished patients displayed greater improvement in healing rates than malnourished patients.²

NPUAP / EPUAP / PPPIA NUTRITION GUIDELINES 2014⁵
Stated the need to provides energy of 30-35 kcal/kg body weight for adults with Pressure Injury OR at risk of pressure injury.
Offer fortified foods and / or high-calorie, high-protein oral nutritional supplements between meals if nutritional requirements cannot be achieved by dietary intake.

Epigran Protein offers:

Essential Protein in pea and oat form

Each sachet of 30g Epigran Protein 30g contains 116 kcal of Pisane® Pea Protein isolate and Oat™ protein as additional nutrients to supplement daily dietary intake.
Pea protein isolate Pisane® are Rich in arginine leucine and isoleucine
Rapid digestion & Low flatulence⁶
Low isoflavons vs soy⁷
Lower allergen & hypersensitivity vs soy/peanut⁸
Neutral effect on blood glucose⁹
Helps in iron absorption¹⁰

Micro Nutrient (Arginine, Glutamine, Leucine)

Arginine, and micronutrients are recommended by NPUAP / EPUAP / PPPIA NUTRITION GUIDELINES for adults with a pressure injury.³
Arginine has been the best-studied component of immunonutrition to wound heal¹¹ ¹² ¹³
Glutamine has been shown to protects against inflammatory injury and stress. ¹² ¹⁴ ¹⁵
Recent ESPEN guideline mentioned that in polymorbid medical patients with bedsore, specific amino acids such as arginine, glutamine, and β-hydroxy β-methylbutyrate (metabolite of leucine) can be added to oral/enteral foods to accelerate the healing of bedsores.

Correct trace element Vitamin A, Vitamin C, Vitamin E, Zinc, Copper, Selenium balance is pivotal for wound healing. ¹⁷ ¹⁸

Addition with Japan Oryza Bird’s Nest Extract

Edible Birds Nests a source of super food with N-acetylneuraminic acid (NANA)
Proven to encompass Epidermal growth factor (EGF) - like activity was detected and partially purified from swiftlet's nest extract.¹⁹
It strongly promote the proliferation human adipose-derived stem cells (hADSCs)²⁰ but not cancer cells. It is able to reduce inflammatory TNF-α in cells²¹

How to consume?

Mix 1 sachet of 30g Epigran Protein, dissolve in 200ml of room temperature water, shake well and consume.

IMPORTANT Notice

Use as nutritional drink to supplement between meals if nutritional requirements cannot be achieved by dietary intake.
Use under medical professional supervision.
Consult a medical professional or nutritionist or healthcare professional for detail dietary need.

Reference:

1. Kaiser et al . JAGS 2010 58 : 1734-11738
2. Leigh B, Desneves K, Rafferty J, Pearce L, King S, Woodward MC, et al. The effect of different doses of an arginine-containing supplement on the healing of pressure ulcers. J Wound Care. 2012;21(3):150
3. The Role of Nutrition for Pressure Ulcer Managemen t: National Pressure Ulcer Advisory Panel, European Pressure Ulcer Advisory Panel, and Pan Pacific Pressure Injury Alliance White Paper. ADVANCES IN SKIN & WOUND CARE & APRIL 2015
4. Dealey C (2000) The Care of Wounds. Blackwell Science, Oxford
5. National Pressure Ulcer Advisory Panel, European Pressure Ulcer Advisory Panel, Pan Pacific Pressure Injury Alliance.
6. Gausseres N, Mahe S, Benamouzig R, Luengo C, Drouet H, Rautureau J, Tome D. 1996. The gastro-ileal digestion of 15N-labelled pea nitrogen in adult humans. Br J Nutr 76(1):75-85.
7. Mazur W, Duke J, Wahala K, Rasku S, Adlercreutz H. 1998. Isoflavonoids and Lignans in Legumes: Nutritional and Health Aspects in Humans. The Journal of nutritional biochemistry 9(4):193-200.
8. Bernhisel-Broadbent J, Sampson HA. 1989. Cross-allergenicity in the legume botanical family in children with food hypersensitivity. The Journal of allergy and clinical immunology 83(2 Pt 1):435-440.
9. Mollard RC, Luhovyy BL, Smith C, Anderson GH. 2014. Acute effects of pea protein and hull fibre alone and combined on blood glucose, appetite, and food intake in healthy young men - a randomized crossover trial. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 39(12):1360-1365.
10. Davidsson L, Dimitriou T, Walczyk T, Hurrell RF. 2001. Iron absorption from experimental infant formulas based on pea (Pisum sativum)-protein isolate: the effect of phytic acid and ascorbic acid. Br J Nutr 85(1):59-63.
11. Leigh B, Desneves K, Rafferty J, Pearce L, King S, Woodward MC, Brown D, Martin R, and Crowe TC: The effect of different doses of an arginine containing supplement on the healing of pressure ulcers. J Wound Care 2012; 21: 150.
12. Oliver Chow and Adrian Barbul, Immunonotrition: Role In Wound Healing. Advances In Wound Care, Vol 3, No 1
13. The Effectiveness of Nutritional Intervention(s) and the Treatment of Pressure Ulcers -- A Systematic Literature Review Siang Choo T, Hayter M, Watson R. Int J Nurs Pract. 2013;19(Suppl 1):19-27
14. Wischemeyer PE: Glutamine and heat shock protein expression. Nutrition 2002; 18: 225.
15. Little MO. Nutrition and skin ulcers. Curr Opin Clin Nutr Metab Care. 2013;16(1):39-49.
16. Neyens JCL, Cereda E, Meijer EP, Lindholm C, Schols JMGA. Arginine-enriched oral nutritional supplementation in the treatment of pressur ulcer: a literature review. Wound Med. 2017;16:46-51.
17. Zinc, Copper, and Selenium Tissue Levels and Their Relation to Subcutaneous Abscess, Minor Surgery, and Wound Healing in Humans. Ursula Mirastschijski & Alicia Martin & Lars N. Jorgensen & Barry Sampson & Magnus S. Ågren. Biol Trace Elem Res (2013) 153:76–83
18. Nutritional therapy for pressure injuries. Rev. Bras. Geriatr. Gerontol., Rio de Janeiro, 2017; 20(4): 562-570
19. Evidence that epidermal growth factor is present in swiftlet's (Collocalia) nest. Kong YC, Keung WM, Yip TT, Ko KM, Tsao SW, Ng MH. Comp Biochem Physiol B. 1987;87(2):221-6.
20. Mechanisms of Edible Bird’s Nest Extract-Induced Proliferation of Human Adipose-Derived Stem Cells Kyung-Baeg Roh,1 Jienny Lee,1 Young-Soo Kim,1 Junho Park,2 Jang-Hyun Kim,3 Jongsung Lee,1 and Deokhoon Park
21. Effect of edible bird’s nest on cell proliferation and tumor necrosis factor- alpha (TNF-α ) release in vitro. Aswir, A. R. and Wan Nazaimoon, W. M. International Food Research Journal 18(3): 1123-1127 (2011)